The Nuclear Nonproliferation Treaty (NPT) regime once again faces a serious challenge in the run-up to the NPT Review Conference scheduled for April 27 to May 22, 2015. This can be attributed to the perceived delay in implementation of commitments made by the states parties at the 2010 NPT Review Conference. Although the 2015 Review Conference is still half a year away, shaky U.S.-Russia relations, the armed conflict directly involving the Israelis and Palestinians, and the outcome of the U.S. mid-term elections will not be conducive to the review process. Both the nuclear-weapon states and the non-nuclear-weapon states should redouble their efforts to narrow their differences on key issues.