The US-China strategic competition, combined with other structural changes such as the global spread of COVID-19, climate change, and competition for technological innovation has dramatically increased uncertainty in Asia. Against this backdrop, the strategic competition between the US and China in the 21st century shows profound differences from the hegemonic competition in the past. The systemic consequences of hyper-uncertainty, as we are witnessing, are protectionism, nationalism, and the proliferation of conflicts and disputes between states. A collection of four papers in this special issue systematically examine the way in which the US-China strategic competition combined with other factors amplify the instability of the regional order, and explain the dual dynamics of competition and cooperation that Asian countries demonstrate in responding to US-China strategic competition and redesigning the regional order.