This article examines Iran-Uzbekistan relations within the regional security context, and the new efforts undertaken in 2019 to solve the security problems via bilateral and regional multinational institutions. It argues that the aggravation of the existing security situation, including geopolitical tensions in the region, contributes to the consolidation of the Iran-Uzbekistan partnership. The anti-Iran measures facilitate the process of reintegrating the region along the historical lines as part of the response to the growing global challenges. There are signs of positive regional dynamics, which can further boost Iran-Uzbekistan cooperation, and presuppose future regional connectivity among all pacified neighbors.